Lisa Mills Pwerle was born in 1970 on MacDonnel Downs Station in Utopia. Utopia is located approximately 200 km North East of Alice Springs, Northern Territory. Her mother is well-known artist, Dolly Mills Petyarre, and her sister Jeannie Mills Pwerle is also a well-established artist. Lisa is married to Damien Petrick whose mother is also a well-known artist, Josie Petrick Kemarre. Lisa lives a traditional life in Utopia with her husband and their daughter Shakira.